Keeping p53 targets quiet
نویسندگان
چکیده
منابع مشابه
Keeping p53 in Check: A High-Stakes Balancing Act
How do regulatory switches achieve high sensitivity within the noisy cellular milieu? Loewer et al. (2010) now use single-cell microscopy to demonstrate that alternative posttranslational modifications allow the tumor suppressor p53 to differentiate between benign breaks in DNA during the cell cycle and deleterious damage caused by mutagens.
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2012
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm3347